Outworld Destroyer + Witch Doctor

Why this works

Picking these two heroes together doesn't give you a clear advantage. On one hand, a good Maledict setup from Witch Doctor can massively amplify the burst damage from Outworld Destroyer's Sanity's Eclipse, deleting a priority target. Paralyzing Cask also provides a decent stun to help OD land his attacks. The problem is that their abilities can actively work against each other. If Outworld Destroyer tries to save a channeling Witch Doctor with Astral Imprisonment, he will immediately cancel the Death Ward. This single negative interaction can cost a teamfight and makes defensive plays very awkward.

The success of this duo comes down to teamfight execution. Early on, they don't offer much to each other from different lanes. Later, everything hinges on whether Outworld Destroyer can land his ultimate on a Maledicted target without accidentally banishing his own Witch Doctor. A coordinated team can make the combo work, focusing down one hero with the combined burst. An uncoordinated one will see Death Wards getting cancelled and Astrals saving the wrong person at the wrong time. It's a high-risk pairing where the potential for a big play is matched by the potential for a big mistake.