Outworld Destroyer + Zeus

Why this works

Seeing two high-damage intelligence cores together might seem like a natural pairing, but their kits don't overlap in a special way. Outworld Destroyer offers a setup with Astral Imprisonment for Zeus's Lightning Bolt, but this is a very basic interaction. Both heroes focus on dealing damage from the back line, but they do it independently. Zeus unloads huge bursts of magic damage on the whole enemy team at once, while Outworld Destroyer focuses on melting a single target with sustained pure damage from his orb. They don't enable each other beyond what any generic stun or save could provide.

During a game, this means they often operate on their own timers. They both need a lot of farm and experience to come online, so they're usually separated for the first part of the match. While Thundergod's Wrath can help clean up a kill for Outworld Destroyer, it does the same for anyone else on the map. The most they do for each other is that Astral Imprisonment can save a poorly positioned Zeus, but ultimately, they are two separate damage threats. Their success relies on the enemy not having the tools to deal with both of them, not on any powerful synergy between them.